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I don't have a 22-250, but my 222 and 223 both love the nosler 55 gr ballistic tip. It figures, those are more expensive than most other bullets! However you can get a good price break on a 1000 pack. Sierra has an equivalent called the 55 gr Blitzking, but my guns dont shoot it as well, and sierra does not offer a 1000 bargain pack.
 
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