If you think she would be happy with an auto, take a look at the Sig 380's. Full metal frame on some so a little tamer recoil. You/She might even want to consider a 9mm from the same Sig line. Plenty of mild rounds and the ammo is cheaper so you can get here to shoot it and be comfortable with it.
All in All though a .38 wheelgun that fits her well is worth a look.
All in All though a .38 wheelgun that fits her well is worth a look.