I have a Glock 21 for carry and for when things "go bump in the night". If it is only for home use maybe you should look at a light-duty shotgun like a 20ga with an 18" barrel. In close quarters, a shotgun will stop an intruder quite reliably. A good 20ga should provide knockdown power without the brutal recoil of the 12ga. If you want a handgun, I'd opt for a Glock 40/45 caliber fullsize pistol or a good revolver, both are good choices for people who aren't very familiar with guns and would be hampered by complicated controls and safeties.