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For the common user, I don't recommend it. In special circumstances it is an option but changes the characteristics of the load.
I do and have used them in rifles. It has been a necessity in some custom rifles. You may even find them recommended for special loads.
I don't think it is a wise choice for common handgun loads, but in special circumstances it is an option.
Hearty handguns, such as unaltered rugers don't seem to mind. You may have reliability problems in some handguns. Primer brands do differ, and some are more sensitive than others.
Generally, rifle primers are thicker and you may have trouble seating them. I would be cautious forcing some of the more sensitive primers. I wouldn't use a progressive press. You need to "feel" what is going on. You may also find your pockets have stretched and you will not be able to go back to handgun primers.
They also will hide pressure signs more readily in a small cartridge.
As others have said ... I would reduce loads 10-15% and stop when the velocity is the same as your previous load with handgun primers.
So yes, they may be used - but no, they are not the same.
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